Until recently, Heavy Metal Toxicity and Detoxification has been disregarded by Western Biomedicine.

However, modern science has increasingly recognised the role of detoxification in managing health, correlating toxins with oxidative stress and the production of free radicals, which result in cellular damage.

Research now shows that free radicals are a critical factor in the development of chronic diseases such as cardiovascular disorders, neurodegenerative diseases (e.g., Alzheimer’s and Parkinson’s), diabetes, and cancer.^1,2 Retained waste material blocks the flow of the ‘life force’ throughout the body, leading to disease over time.

THE MICROBIAL THEORY OF DISEASE PROGRESSION

German microbiologist, physician, and researcher, Professor Günther Enderlein, demonstrated that micro-organisms in the human body could develop upward from apathogenic forms (non-pathogenic) via physiological early phases into pathogenic agents capable of causing disease. By observing fresh blood under a darkfield microscope, he concluded that the internal environment, or ‘milieu intérieur,' was solely responsible for the development of viral, degenerative, and bacterial conditions. His findings have been further supported by studies on how alterations in the gut microbiome and systemic exposure to heavy metals can contribute to chronic inflammation and immune dysfunction.^3,4

Heavy metals, such as mercury and cadmium, are known to disrupt mitochondrial function, contributing to oxidative stress and cellular damage that prevent the proper regulation of the human internal matrix—a concept aligned with Enderlein’s work.⁵

DENTAL AMALGAMS AND HEAVY METAL CONTAMINATION

Amalgams in teeth can be significant sources of mercury, while palladium, silver, tin, and aluminium also introduce cellular contamination. These heavy metals impede cell metabolism, tissue regulation, and immune function, contributing to the emergence of bacterial or viral mono-infections. Healthcare professionals must evaluate heavy metal toxicity using validated protocols to address patients' exposure to these sources of contamination properly.

THE CRITICAL ROLE OF ZINC

Heavy metals displace zinc from the internal environment, disrupting its many biological functions. Zinc has been proven essential for immune regulation, enzymatic reactions, and tissue repair. Recent studies highlight zinc’s role in maintaining the structural and functional integrity of the immune system, particularly in supporting the T-cell response against infections, including bacterial and viral pathogens.^6,7 Zinc supplementation is now frequently incorporated into integrative heavy metal detox protocols. Its critical roles include:

Enhancing the absorption and action of vitamins, especially the B-complex vitamins.
Supporting over 200 enzymatic functions, including those related to digestion and metabolism.
Facilitating DNA synthesis, immune system regulation, and reproductive health.

ADVANCES IN DETOXIFICATION THERAPIES

Dr Dietrich Klinghardt’s Heavy Metal Detox Protocol: In detoxification therapies, it is imperative to address heavy metal toxicity with a personalised approach tailored to patients' metabolic status and toxicological burden. Dr. Dietrich Klinghardt’s protocol emphasises the use of:

Wild garlic to bind heavy metals in the bloodstream and kidneys.
Chlorella pyrenoidosa (algae) to remove toxins from the intestine and prevent reabsorption.
Coriander (cilantro), which facilitates intracellular release of heavy metals into the matrix.

Dosage and application of cilantro tincture: give 2 drops 2 times /day in the beginning, taken just before a meal or 30 minutes after taking chlorella (cilantro causes the gallbadder to dump bile — containing the excreted neurotoxins — into the small intestine. The bile-release occurs naturally as we are eating and is much enhanced by cilantro. If no chlorella is taken, most neurotoxins are reabsorbed on the way down the small intestine by the abundant nerve endings of the enteric nervous system). Gradually increase dose to 10 drops 3 times/day for full benefit. During the initial phase of the detox cilantro should be given 1 week on, 2 to 3 weeks off.

Dosage and application of Chlorella: start with 1 gram 3 to 4 times a day. This is the standard maintenance dosage for grown ups for the 6 to 24 months of active detox. During the more active phase of the detox (every 2 to 4 weeks for 1 week), whenever cilantro is given, the dose can be increased to 3 grams 3 to 4 times per day (1 week on, 2 to 4 weeks back down to the maintenance dosage). Take 30 minutes before the main meals and at bedtime. This way chlorella is exactly in that portion of the small intestine where the bile squirts into the gut at the beginning of the meal, carrying with it toxic metals and other toxic waste. These are bound by the chlorella cell wall and carried out via the digestive tract. When amalgam fillings are removed, the higher dose should be given for 2 days before and 2 to 5 days after the procedure (the more fillings are removed, the longer the higher dose should be given). No cilantro should be given around the time of dental work. During this time we do not want to moblise deeply stored metals in addition to the expected new exposure. If you take Vitamin C during your detox program, take it as far away from Chlorella as possible (best after meals).

Side effects: most side effects reflect the toxic effect of the mobilised metals which are shuttled through the organism. This problem is instantly avoided by significantly increasing the chlorella dosage, not by reducing it, which would worsen the problem (small chlorella doses mobilise more metals then are bound in the gut, large chlorella doses bind more toxins then are mobilised). Some people have problems digesting the cell membrane of chlorella. The enzyme cellulase resolves this problem. Cellulase is available in many health food stores in digestive enzyme products. Taking chlorella together with food also helps in some cases, even though it is less effective that way. C.vulgaris has a thinner cell wall and is better tolerated by people with digestive problems.

Dosage and application of garlic: 1 to 3 capsules freeze dried garlic after each meal. Start with 1 capsule after the main meal per day, slowly increase to the higher dosage. Initially the patient may experience die-off reactions (from killing pathogenic fungal or bacterial organisms). Use 5 to 10 drops bear-garlic on food at least 3 times per day.

STUDIES

Professor Yoshiaki Omura demonstrated that coriander could effectively mobilise heavy metals such as mercury from brain tissue and organs into the extracellular space for elimination. Recent studies affirm these findings, showing that combining chlorella and coriander enhances chelation efficacy, especially when used alongside adjunct therapies like N-acetylcysteine (NAC) or glutathione supplementation.^8,9

To safely implement this treatment, it is critical to ensure that the liver and kidneys are robust enough to handle the increased detoxification load. The addition of antioxidants such as vitamin C and coenzyme-Q-10 supports mitochondrial function during the chelation process.

MATRIX FUNCTION IN DETOXIFICATION

The ‘basic system' theory, as articulated by Alfred Pischinger, defines the interstitial substance — the soft connective tissue matrix — as a central regulator of detoxification. It comprises glycoproteins, proteoglycans, and collagen, serving as the medium through which metabolic waste, nutrients, and immune signals flow. Research confirms that maintaining healthy connective tissue is essential for detoxification and systemic health, as impaired matrix function is now linked to fibrotic diseases and immune dysregulation.¹⁰ Therapies focusing on connective tissue health — such as collagen supplementation and glycoprotein support — are gaining prominence in integrative medicine.

References

Pizzino G, Bitto A, Interdonato M, et al. Oxidative stress: Harms and benefits for human health. Oxidative Medicine and Cellular Longevity. 2017:8416763. doi:10.1155/2017/8416763.
Uttara B, Singh AV, Zamboni P, Mahajan R. Oxidative stress in neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options. Current Neuropharmacology. 2009;7(1):65–74.
Katsnelson BA, Privalova LI, Kuzmin SV, et al. Impact of heavy metals on gut microbiota. Environmental Health Perspectives. 2021;129(2):25002. doi:10.1289/EHP7324.
Miller FW, Pollard KM, Parks CG, et al. Autoimmune diseases triggered by environmental exposures. Immunological Reviews. 2011;243:98–112.
Andreani T, Kiouptsi K, Weiss E, Liehn EA. Heavy metals and the vascular system. International Journal of Molecular Sciences. 2022;23(12):6779.
Prasad AS. Zinc is an antioxidant and anti-inflammatory agent: Its role in human health. Frontiers in Nutrition. 2020;7:696. doi:10.3389/fnut.2020.00696.
Wessels I, Haase H, Engelhardt G, Rink L. Zinc supplementation and its effects on immune regulation. Nutrients. 2021;13(2):446. doi:10.3390/nu13020446.
Aschner M, Costa LG. Chelation therapy and metal detoxification. Toxics. 2017;5(4):28. doi:10.3390/toxics5040028.
Negrão F, Merlotti LV, Gomes M. Cilantro and Chlorella as natural chelators. Environmental Science and Pollution Research. 2020;27(25):31309–31320.
Aposhian HV, Maiorino RM, Xu Z, et al. Mobilization of heavy metals during chelation therapy. Toxicology and Applied Pharmacology. 1995;134(2):163–169.
Theocharis AD, Skandalis SS, Tzanakakis GN, Karamanos NK. Proteoglycans in health and disease. Advances in Drug Delivery Reviews. 2010;62:395–420.

your guide to healthy living

Detoxification and Heavy Metal Toxicity

Until recently, Heavy Metal Toxicity and Detoxification has been disregarded by Western Biomedicine.

However, modern science has increasingly recognised the role of detoxification in managing health, correlating toxins with oxidative stress and the production of free radicals, which result in cellular damage.

THE MICROBIAL THEORY OF DISEASE PROGRESSION