This is an objective, independently written product review on the comprehensive microbiome support formula: Ther-Biotic® Synbiotic capsules. This next-generation shelf-stable vegetarian blend of 30 billion colony forming units (CFU) contain seven probiotics and a well-tolerated low-FODMAPTM certified prebiotic: SunFiber® for synergistic microbiome support.
Our digestive system contains a complex ecosystem – a microbiome of probiotics (beneficial gut bacteria) and prebiotics (non-digestible fibers that nourish and support the growth of microorganisms). It is an ecosystem due to the synbiotic co-evolution along with us as their host.
THE ENTOURAGE EFFECT
When probiotics and prebiotics are supplemented together (called synbiotics) their unique mechanisms of actions collaborate to produce a more profound effect than they do alone1 in the promotion and healthy functioning of the digestive tract. This is why Ther-Biotic® Synbiotic capsules were created.
WHY DO WE NEED PROBIOTICS?
Our microbiome has numerous functions such as the production of various nutrients, prevention of infections caused by intestinal pathogens, and the modulation of our immune response. Therefore, the modification and the activity of the intestinal microbiota (microorganisms) present in the gastrointestinal tract is necessary in order to achieve, restore, and maintain a favourable balance in the ecosystem to improve overall health.
With the digestive system making up about 70 percent of the body’s innate immune function, increasing friendly bacteria can promote a healthy immune response. Signs of an unhealthy gut include gas, bloating, constipation, diarrhea, and heartburn. A healthy gut, by contrast, will have less difficulty processing foods and eliminating waste. Synbiotics help to reestablish the healthy gut flora that support relief from the occasional digestive discomforts associated with an unbalanced GI environment.
HOW COULD I HAVE COMPROMISED MY GUT HEALTH?
A diet high in processed foods and added sugars can negatively impact the number of good bacteria in the gut, leading to imbalance. What’s more, bacteria influence our cravings for certain foods by modifying our taste buds and producing neurotransmitters such as dopamine and serotonin. These outcomes can cause increased sugar cravings that might damage your gut even more.
Bariatric surgery leads to alterations in gut flora and transit time. Supplementing with the healthy probiotics and prebiotic fibers found in synbiotics can help to ensure balance in the GI tract after modification.
Food intolerances occur when the body is unable to properly digest certain foods and unpleasant symptoms like bloating and gas may follow.
Antibiotics are often nonspecific in bacteria that they kill and are just as likely to damage healthy gut flora as they are to impair harmful pathogens. By replenishing beneficial bacteria in the microbiome, synbiotics can support healthy digestive function both during and after antibiotic therapy.
Travellers know that our microflora are influenced by changes in the environment. As a result, it is not uncommon to experience digestive symptoms while traveling long distances. Packing a synbiotic ensures easy access to beneficial probiotic strains.
Ther-Biotic® Synbiotic is a powerful, broad-spectrum probiotic with strains identified to offer the following benefits:
- Reduce symptoms of digestive discomfort such as bloating and flatulence
- Support regular bowel movements and reduces constipation
- Improve symptoms of respiratory infections, including colds and flu
- Restore gut bacteria after antibiotics
- Supports immune and metabolic function
- May support healthy inflammation modulation, where inflammation is associated with occasional digestive discomfort.
To ensure the timely release of this formulation, Ther-Biotic® Synbiotic is protected by a delayed-release capsule (DR Caps) technology which allows the probiotics and prebiotic to be released at the most beneficial location along the GI tract.
This improves the survival, implantation, and metabolic impact of the probiotic strains. DR Caps has been scientifically shown to enhance the survivability of probiotics and to deliver them effectively to the intestines. Specialized moisture-resistant and desiccant-lined packaging further enhances the survivability of the strains. The capsules are vegetarian and each ingredient included in this synbiotic is also individually identified and fully disclosed on the product label:
|Serving size: 1 Capsule
||Amount per serving
|Probiotic Blend (30 Billion CFU)
|Lactobacillus Plantarum UALp-05™
||9.3 Billion CFU
|Bifidobacterium lactis UABla-12™x
||8.0 Billion CFU
|Lactobacillus rhamnosus GG
||5.5 Billion CFU
|Lactobacillus acidophilus DDS®-1
||3.0 Billion CFU
|Lactobacillus paracasei UALpc-04™
||3.0 Billion CFU
|Lactobacillus reuteri UALre-16™
||0.6 Billion CFU
|Bifidobacterium bifidum UABb-10™
||0.6 Billion CFU
|Sunfiber® (partially hydrolyzed guar gum/PHGG)
*Daily value not established.
Delayed release capsule (hydroxypropyl methylcellulose, gellan gum, and water), silica, and ascorbyl palmitate.
‡DDS® and all UA strains are registered trademarks of UAS Laboratories LLC and used under license.
‡‡Sunfiber®, a water-soluble dietary fiber, is a registered trademark of Taiyo International, Inc.
PROBIOTIC STRAINS EXPLAINED
Lactobacillus acidophilus DDS®-1
A widely recognized probiotic that promotes the healthy functioning of the gut and is highly resistant to gastric acid, bile salts, and proteases. It aids in the digestion of gluten and casein proteins and ferments a variety of carbohydrates that escape digestion in the upper gastrointestinal tract, including fructooligosaccharides (FOS) and galactooligosaccharides (GOS), releasing short chain fatty acids important for intestinal barrier function. Studies have shown that L. acidophilus promotes the absorption of micronutrients such as vitamins and minerals. Studies have also demonstrated that L. acidophilus DDS®-1 has immunomodulatory effects and can support the immune system. L. acidophilus is one of two probiotic strains shown to improve abdominal pain and symptom severity scores with a corresponding normalization of bowel habits in adults with IBS.2
Lactobacillus plantarum UALp-05™
Generally lacking in the gut microecology of individuals consuming a standard Western diet. L. plantarum effectively metabolizes oligofructans, semi-resistant polysaccharides found in vegetables. A very hardy species, L. plantarum is highly resistant to gastric acid, bile, and proteases; it also has a strong ability to assimilate cholesterol under various intestinal conditions. L. plantarum induces the expression of genes regulating tight junction formation, thereby improving intestinal barrier function. It strongly attaches to human colonocytes, competing with undesirable bacteria and promoting a balanced microbiota. L. plantarum supports a healthy immune response and reduces the risk of antibiotic-associated diarrhea3 and improves symptoms of irritable bowel syndrome.4,5
Bifidobacterium lactis UABla-12™
Supports normal bowel movement frequency and stool consistency. B. lactis has excellent adherence to intestinal mucin, a prerequisite for competition with undesirable bacteria. It helps to digest proteins such as casein and gliadin. Supplementation with B. lactis has been shown to support cellular immunity and balances bifidobacterial/enterobacteria counts in elderly individuals. B. lactis may support a healthy plasma IgG response to vaccination.
Lactobacillus paracasei UALpc-04™
Has excellent acid-tolerance and is highly resistant to pepsin and pancreatin. It is able to ferment inulin and phleins, releasing short chain fatty acids required for intestinal barrier function. It supports the immune response through the production of compounds that support the immune balance, while activating the innate immune system.
Lactobacillus rhamnosus GG
Produces more peptidases than any other Lactobacillus species, aiding in the digestion of proteins. L. rhamnosus supports healthy immune function and promotes stronger epithelial barrier function, as well as reduce the risk of antibiotic associated diarrhea.
Bifidobacterium bifidum UABb-10™
Aids in the digestion of casein proteins through the production of a variety of β-galactosidases and other enzymes which degrade lactose. B. bifidum has been shown to efficiently degrade mucin, and due to their proximity to the immune system, mucin-degrading bacteria are in a prime location to influence the epithelial barrier and host response. Studies have shown that B. bifidum strengthens intestinal barrier function and promotes a healthy microbiome balance.
Lactobacillus reuteri UALre-16™
Found in different body sites including the gastrointestinal tract, urinary tract, skin, and breast milk. With the production of organic acids, ethanol, and reuterin, L. reuteri supports a balanced microbiome. It also may benefit the immune system, by influencing cytokine production while promoting regulatory T-cell development and function. In addition, by bearing the ability to strengthen the intestinal barrier, the colonization of L. reuteri may decrease the microbial translocation from the gut lumen to the surrounding tissues, supporting a healthy inflammatory response.
Sunfiber®, a well-tolerated low-FODMAPTM prebiotic is the element in this formulation that is a water soluble, gluten-free fiber derived from partially hydrolyzed guar gum. Due to its slow fermentation process, Sunfiber® is gentle and well-tolerated by even the most sensitive systems, producing less gas and bloating than other prebiotics with faster fermentation rates. Clinically demonstrated to improve the survival, implantation, and metabolic impact of the probiotic strains included in Ther-Biotic® Synbiotic, completes the innovative impact of this synbiotic as it synergistically supports overall GI health.
With 30 billion CFU per capsule and strain identification for optimal transparency, Ther-Biotic® Synbiotic provides a powerful, broad-spectrum probiotic with Sunfiber®, the prebiotic nutrition that the microbiome requires to maintain healthy homeodynamic balance and offering an more profound entourage effect on GI ecology.
DOSAGE, HOW TO TAKE AND STORE
Adults: 1 capsule daily or as directed by a healthcare professional.
Children: As directed by a healthcare professional.
30 capsules per bottle. Do not swallow capsules with hot drinks as heat kills bacteria.
Storage: Ther-Biotic® Synbiotic is shelf-stable without refrigeration for up to two years. Store in a cool, dry place (below 25 0C) away from direct light.
Free of the following common allergens: milk/casein, eggs, fish, shellfish, tree nuts, peanuts, wheat, gluten, and soybeans. Contains no artificial colors, flavors, or preservatives.
SIDE EFFECTS AND WARNINGS
Caution: If you are pregnant, nursing, have a medical condition, or taking prescription drugs, consult your physician before using this product. KEEP OUT OF REACH OF CHILDREN.
The information published here, does not intend to diagnose, treat, cure or prevent any disease. The product reviewed has not been evaluated by any regulatory body and is not intended to diagnose treat, cure or prevent any disease. The information given here is not meant to be a substitute for seeing a health professional. It is our opinion only, based on several years of research, in consultation with world experts. We’re sure you’ll find it useful, but please use it wisely and always exercise common sense.
Editor’s note: For more articles on probiotics, see: The Microbiome & Internal Balance. Probiotics and their conversations in our bodies and The difference between prebiotics & probiotics.
- Markowiak P, Śliżewska K. Effects of Probiotics, Prebiotics, and Synbiotics on Human Health. Nutrients. 2017 Sep 15;9(9):1021. doi: 10.3390/nu9091021. PMID: 28914794; PMCID: PMC5622781.
- Martoni CJ, Srivastava S, Leyer GJ. Lactobacillus acidophilusDDS-1 and Bifidobacterium lactis UABla-12 Improve Abdominal Pain Severity and Symptomology in Irritable Bowel Syndrome: Randomized Controlled Trial. Nutrients. 2020 Jan 30;12(2):363. doi: 10.3390/nu12020363. PMID: 32019158; PMCID: PMC7071206.
- Lönnermark E, Friman V, Lappas G, Sandberg T, Berggren A, Adlerberth I. Intake of Lactobacillus plantarum reduces certain gastrointestinal symptoms during treatment with antibiotics. J Clin Gastroenterol. 2010 Feb;44(2):106-12. doi: 10.1097/MCG.0b013e3181b2683f. PMID: 19727002.
- Ducrotté P, Sawant P, Jayanthi V. Clinical trial: Lactobacillus plantarum 299v (DSM 9843) improves symptoms of irritable bowel syndrome. World J Gastroenterol. 2012 Aug 14;18(30):4012-8. doi: 10.3748/wjg.v18.i30.4012. PMID: 22912552; PMCID: PMC3419998.
- Nobaek S, Johansson ML, Molin G, Ahrné S, Jeppsson B. Alteration of intestinal microflora is associated with reduction in abdominal bloating and pain in patients with irritable bowel syndrome. Am J Gastroenterol. 2000 May;95(5):1231-8. doi: 10.1111/j.1572-0241.2000.02015.x. PMID: 10811333.