Product Review – Sinulex® Forte C Fizzy

This is an objective, independently written product review on Sinulex® Forte C Fizzy – a diabetic friendly, non-drowsy natural botanical effervescent for the symptomatic relief of sinusitis, hay fever (allergic rhinitis) and respiratory tract infections.

The ingredients in Sinulex^®C Forte Fizzy have clinical data to show its efficacy in the fight against viral and bacterial infections. The result: a reduction in the severity of symptoms of acute inflammation of the paranasal sinuses, prevention of bacterial infections and may shorten the duration of a cold, flu or sinusitis.

Sinulex^® Forte C Fizzy is lactose-, GMO-, soya-, tartrazine- and sugar-free, and does not contain pseudoephedrine or any stimulants such as caffeine.

INGREDIENTS

Sinulex^® Forte C Fizzy s is a natural product of pharmaceutical grade quality containing 500 mg of Echinacea purpurea extract, 300 mg of L-ascorbic acid (vitamin C), 200 mg of Horseradish extract, 16.7 mg of zinc gluconate (equivalent to 2 mg elemental zinc) and 8.33 μg of Vit D₃ (Cholecalciferol 333 IU).

Lets have a look at the ingredients

Echinacea

American Indians were the first to use Echinacea for various ailments including sore throat, tonsillitis and cough. The main indications nowadays are for the adjuvant therapy and prophylaxis of recurrent infections of the upper respiratory tract (common colds).

Echinacea has an antibacterial¹ and antiviral effect on many micro-organisms that cause colds, flu and upper respiratory tract infections. Symptoms associated with virus-induced common colds and other respiratory complications are the result of the increased levels of pro-inflammatory cytokines, rather than direct effects of virus replication.² This is where the use of Echinacea becomes important in the healing of respiratory infections.

There have been numerous studies demonstrating the immune modulatory properties of Echinacea.^3-9

L-ascorbic acid (vitamin C) is an important water-soluble vitamin which therefore cannot be stored in sufficient levels in the body. Well known for its ability to fight colds and flu, vitamin C is also used to lower, balance and maintain healthy blood histamine levels. Individuals with low vitamin C levels may therefore experience more intense symptoms of allergic rhinitis.

Vitamin C has well-documented beneficial effects on the immune system¹⁴ and is an essential biological antioxidant used to ameliorate a wide variety of infections. In addition, vitamin C prolongs the survival of immune cells that fight against invading viruses.

According to test results¹⁵ there’s up to 100 times more vitamin C in our white blood cells than in the plasma (fluid component) of our blood.

Vitamin C reduces the severity of cold symptoms, is an antiviral,¹⁶and a review published in the Cochrane Central Register of Controlled Trials in 2000 revealed that vitamin C reduces the severity and duration of cold symptoms.¹⁷

The overwhelmingly positive body of evidence relating to the immune support benefits of vitamin C and its role in the nutritional management of the common cold cannot be ignored.

Horseradish extract is a decongestant herb with a robust mucolytic action, used to relieve respiratory mucus, nasal congestion and catarrh of the respiratory tract. Horseradish contains mustard oils that irritate mucous membranes, effectively alleviating excessive accumulation of mucus. In the clinical setting, horseradish has been demonstrated as having antispasmodic and anti-inflammatory¹⁰ effects on the respiratory tract. Allyl isothiocyanate, a constituent of horseradish, is a potent antimicrobial^11,12 that may be effective in treating influenza, respiratory tract infections, and sinus inflammation.

Also known as kren or krenweiberl, horseradish has a long history of medicinal use in parts of Austria and Bavaria in fighting a variety of conditions including influenza, respiratory ailments, and scurvy, due to its high vitamin C content. The flavonoids in horseradish make this herb an antioxidant powerhouse.¹³

Zinc Gluconate

Zinc is an important mineral found in almost every cell in the human body and is very well absorbed in gluconate form. Zinc has been shown to reduce the duration of common colds with decreased symptom severity. It is of key importance in many biological processes, such as the promotion in the activity of about 100 enzymes. Deficiency in zinc is often associated with an increased risk of infection. Zinc may interfere with rhinovirus adhesion, protecting plasma membranes from microbial toxins. Zinc increase immunity against several viruses and may even interfere with the replication of certain viruses.

Vit D₃ is natural vitamin D, which is identical to the vitamin D our body makes naturally from sunlight. Vitamin D₃ is much better absorbed than vitamin D, making it approximately 87% more effective in raising and maintaining blood levels of vitamin D.

Vitamin D is vitally important for the proper functioning and strengthening of the immune system. Acute respiratory tract infections were responsible for approximately 2.38 million deaths worldwide in 2016. A wealth of mechanistic and clinical data show that vitamin D plays a critical (and complex) role in supporting the immune system. There are vitamin D receptors and activating enzymes on the surfaces of all white blood cells.

Inadequate and low intake and status of vitamin D is widespread, leading to a decrease in resistance to infections and as a consequence, associated with frequent colds and flu. In 2017, analyses of prospective clinical trials showed that taking vitamin D reduces the odds of developing a respiratory infection by approximately 42% in people with low baseline levels vitamin D.

Sinulex^® Forte C Fizzy comes in a tube of 12 effervescent tablets.

DOSAGE AND DIRECTIONS FOR USE

It is recommended to take this dosage consecutively for at least 5 days.

Acute dosage:

Adults and children above 12 years: dissolve 1 tablet in 200 ml room temperature water three times a day.
Children 6 to 12 years: dissolve ½ a tablet in 200 ml room temperature water three times a day.

Maintenance dosage:

Adults and children above 12 years: dissolve 1 tablet in 200 ml room temperature water once daily.
Children 6 to 12 years: dissolve ½ a tablet in 200 ml room temperature water once daily or as prescribed by your healthcare provider.

Do not exceed the recommended or prescribed daily dosage.

SIDE EFFECTS AND WARNINGS

Known hypersensitivity (allergies) to any of the mentioned ingredients.
Safety during pregnancy and lactation has not been established.
Do not take this medication if you have progressive systemic and autoimmune disorders such as TB, connective tissue disorders, collagen vascular diseases and related diseases such as lupus, rheumatoid arthritis or psoriasis.
Do not store above 25°C and keep out of reach of children.
Do not use after date of expiry.

For more information, visit sinulex.global

Sinulex^® Forte C Fizzy is available without a prescription from all leading pharmacies. Buy now

Editor’s note:

Confused about the difference between sinusitis and allergies, click here. For more information on how to manage sinusitis naturally, click here.

The information published here, does not intend to diagnose, treat, cure or prevent any disease. The product reviewed has not been evaluated by any regulatory body and is not intended to diagnose treat, cure or prevent any disease. The information given here is not meant to be a substitute for seeing a health professional. It is our opinion only, based on several years of research, in consultation with world experts. We’re sure you’ll find it useful, but please use it wisely and always exercise common sense.

References

Barrett B. Medicinal properties of Echinacea: A critical review. Phytomedicine 2003;10:66-86.
Sharma M, Anderson SA, Schoop R, Hudson JB. Induction of multiple pro-inflammatory cytokines by respiratory viruses and reversal by standardized Echinacea, a potent antiviral herbal extract. Antiviral Res. 2009;83(2):165-170.
Bauer R. Chemistry, analysis and immunological investigations of Echinacea phytopharmaceuticals. In: Wagner H, ed. Immunomodulatory Agents from Plants. Berlin: Birkhäuser Verlag, 1999: 41-88.
Sendchina DS, et al. Effects of Echinacea extracts on macrophage antiviral activities. Phytother Res 2010;24(6):810-816.
Bauer R, Liersch R. Echinacea. In: Hänsel H, Keller K, Rimpler H, Schneider G, eds. Hager´s Handbuch der Pharmazeutischen Praxis. Berlin: Springer Verlag, Vol. 4, 1992: 1-34.
Blumental M, sen. ed. The Complete German Commission E Monographs. Binghampton, New York: The Haworth Press, 1998.
Brinkeborn RM, Shah DV, Degenring FH. 1999. Echinaforce and other Echinacea fresh plant preparations in the treatment of the common cold: A randomized, placebo controlled, double-blind clinical trial. Phytomedicine1999;6(1):1-6.
Maass N, Bauer J, Paulicks BR, Böhmer BM, Roth-Maier DA. 2005. Efficiency of Echinacea purpurea on performance and immune status in pigs. Journal of Animal Physiology and Animal Nutrition 2005:89:244-252.
Woelkart K, Koidl CH, Grisold A, et al. Bioavailability and pharmacokinetics of alkamides from the roots of Echinacea angustifolia in humans. J Clin Pharmacol 2005;45,:683-689.
Marzocco S, Calabrone L, Adesso S, et al. Anti-inflammatory activity of horseradish (Armoracia rusticana) root extracts in LPS-stimulated macrophages. Food Funct 2015;6(12):3778‐3788. doi:10.1039/c5fo00475f
Goos K-H, Albrecht U, Schneider B. Efficacy and safety profile of a herbal drug containing nasturtium herb and horseradish root in sinusitis, acute bronchitis and acute urinary tract infection in comparison with other treatments in the daily practice/results of a prospective cohort study. Arzneimittelforschung 2006;56(3):249-257.
Tomita T, Sato N, Arai T, et al. Bacterial activity of a fermented hot-water extract from Stevia rebaudiana bertoni towards enterohemorrhagic Escherichia coli O157:H7 and other food-borne pathogenic bacteria. Microbiol Immunol 1997;41(12)1005-1009.
Gafrikova M, Galova E, Sevcovicova A, Imreova P, Mucaji P, Miadokova E. Extract from Armoracia rusticana and its flavonoid components protect human lymphocytes against oxidative damage induced by hydrogen peroxide. Molecules 2014;19(3):3160‐3172. Published 2014 Mar 14. doi:10.3390/molecules19033160
Carr AC, Maggini S. Vitamin C and immune function. Nutrients 2017;9(11):1211. Published 2017 Nov 3. doi:10.3390/nu9111211
Leibovitz B, Siegel BV. Ascorbic acid and the immune response. Adv Exp Med Biol 1981;135:1-25.
White LA, Freeman CY, Forrester BD, Chappell WA. In vitro effect of ascorbic acid on infectivity of herpesviruses and paramyxoviruses. J Clin Microbiol 1986;24(4):527-31.
Douglas RM, et al. Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev 2000;2:CD000980.