The controversy around high-dose nutrients continues to be a thorn in the side of conventional medicine and even governments. There are good reasons for this, some of which are understandable. The RDA or recommended daily dose of vitamins was established to identify the lowest dose that would prevent deficiency diseases, but it has little to do with the maximum doses required for optimum health. Orthomolecular medicine has gone one step further, namely to use even higher doses of nutrients for their particular biochemical and biological effects on the body.